SSRIs / SNRIs
- Target serotonin & norepinephrine
- 4–8 weeks to show full effect
- May not work for treatment-resistant cases
- Must be taken daily, indefinitely
FDA-approved SPRAVATO® (esketamine) nasal spray for treatment-resistant depression. Most insurance accepted. Free consultation with our care team, under the guidance of a Johns Hopkins-trained psychiatrist.
Based on pooled analysis of TRANSFORM-1 & TRANSFORM-2 Phase 3 trials. Popova V, et al. J Affect Disord. 2023.
30 minutes · No cost · No obligation
Most patients who benefit from SPRAVATO® share these things in common. If most of these apply to you, you may be a strong candidate for treatment.
Book My Free EvaluationSPRAVATO® is typically covered by these providers. We'll verify your specific plan for free before you commit to treatment.
Unlike traditional antidepressants that target serotonin and can take 4–8 weeks to work, SPRAVATO® targets a different system in the brain — and many patients experience relief in days, not months.
SPRAVATO® works on glutamate, the brain's main excitatory neurotransmitter. Traditional antidepressants target serotonin. This is why SPRAVATO® may work when SSRIs and SNRIs have not.
Many patients report improvement within the first one to two weeks. Traditional antidepressants typically take four to eight weeks — if they work at all.
Self-administered as a nasal spray during in-clinic sessions at our REMS-certified Frederick, MD location. You stay for monitoring after each dose to ensure safety.
A straightforward path designed to feel calm and supported — not clinical and confusing. Each step builds on the last.
A no-cost call with our team to confirm you're a candidate, answer your questions, and verify your insurance coverage at no charge. No commitment required.
A thorough evaluation with our Johns Hopkins-trained psychiatrist to confirm diagnosis, review your treatment history, and build a personalized plan.
Self-administer the nasal spray in a quiet, private room at our Frederick, MD clinic. Stay for two hours of monitoring while our team supports you. Please arrange a ride home — no driving the same day.
Track your progress with standardized rating scales at every visit. Adjust your plan as needed. We coordinate with your therapist or primary care doctor as appropriate.
Ready to start? It begins with a free, no-obligation phone call.
Book My Free Consultation
Johns Hopkins-Affiliated
Founder & Lead Psychiatrist, Bright Horizons Psychiatry
Completed Psychiatry Residency at Johns Hopkins University — one of the world's top-ranked psychiatry programs — with a focus on mood disorders and advanced treatments.
American Board of Psychiatry and Neurology certified.
Treatment-resistant depression, SPRAVATO®, Deep TMS, IM ketamine, and complex mood disorders in adults.
Bright Horizons is a Risk Evaluation and Mitigation Strategy (REMS) certified clinic, meeting FDA requirements for safe esketamine administration.
"Most patients who come to me have tried everything. My job is to take that seriously, look at what hasn't worked and why, and offer treatments that actually fit the science of what's happening in their brain. People deserve more than another prescription."— Dr. Amir Etesam, MD
NPI: 1588144588 · License: Maryland
Everything you need to know before your free consultation. Don't see your question? Call us or ask during your call.
Yes. SPRAVATO® is FDA-approved and typically covered by most major insurance plans, including Aetna, Blue Cross Blue Shield, Cigna, Tricare, United Healthcare, Maryland Medicaid, and Medicare.
Coverage usually requires prior authorization. We handle the entire prior authorization process for you at no cost. We'll also verify your specific plan and any out-of-pocket costs during your free consultation so you know exactly what to expect.
The most common side effects during the two-hour monitoring period are temporary and typically resolve before you leave the clinic. They include:
Because of these effects, you must be monitored on-site for two hours after each dose and cannot drive for the rest of the day. Our clinical team monitors your blood pressure, comfort, and safety throughout. Serious side effects are rare and the medication is administered under FDA REMS-certified safety protocols.
Many patients begin to notice improvement within the first one to two weeks of treatment — in contrast to traditional antidepressants, which typically take four to eight weeks.
The standard course is twice-weekly sessions for the first four weeks (induction phase), followed by less frequent maintenance sessions. Response is monitored at every visit using standardized rating scales. Results vary by patient — some respond quickly; others need the full induction phase. Your psychiatrist will set expectations during your initial evaluation.
Each session lasts approximately two hours at our Frederick, MD clinic (7360 Guilford Dr STE 100) in a quiet, private treatment room. Here's what to expect:
No. FDA REMS safety protocols require that you do not drive, operate machinery, or perform any activity requiring full alertness for the remainder of the day after each SPRAVATO® session.
You must arrange transportation home from each visit — a family member or friend, rideshare (Uber or Lyft), or a taxi. The next day, you can typically return to normal activities, including driving, unless your psychiatrist advises otherwise.
Getting started is straightforward and risk-free:
The free consultation has no cost and no obligation — it's simply a conversation to see if SPRAVATO® is right for you.
Still have questions? That's exactly what your free consultation is for.
Book My Free Consultation30 minutes · No cost · No obligation
You've tried enough things that didn't work. SPRAVATO® might be different — and the only way to know is a 30-minute conversation with our team.